Evaluation of Serum Leptin Level in Males with Elevated Blood Pressure

Abstract

Leptin is a hormone secreted from adipose tissue, proved to be related to inflammatory, hemostatic, and metabolic factors, and thought to be involved in the development of hypertension. We aim to evaluate serum leptin levels and lipid profile in males with elevated blood pressure to be compared with healthy controls males of matched body mass index (BMI) and age. The present study were included 50 subject, 24 healthy controls males whose BMI (Mean±SD 27.6±4.9) as control group and 26 hypertensive males with essential hypertension whose BMI (Mean±SD 28.3±3.4), those two groups were aged and BMI matched Fasting serum leptin level, triglyceride (TG), total serum cholesterol, high density lipoprotein(HDL) and low density lipoprotein(LDL) were measured. Leptin was found to be significantly higher in the hypertensive males (group2) when compared with the control group (group1) (21.5±2.3ng/ml against 14.3±1.4 ng/ml, respectively; p<0.03), while a very high significant difference in triglyceride, systolic and diastolic blood pressure (p <0.0001) and a significant difference in cholesterol was (p 0.01), LDL was (p<0.01) and HDLwas (p<0.05). The present study concluded that male patients with elevated blood pressure had significantly higher serum leptin level compared with healthy subjects of a same BMI. More over patients with hypertension had an unfavorable lipid profile.